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(Littell, Corcoran, & Pillai 2008) 
Introductory video from Yale University's informative video series on systematic reviews:
Systematic reviews are an integral part of Evidence Based Practice. They are types of syntheses, which sit in the middle of the 6S Pyramid of filtered or pre-appraised evidence. The 6S Pyramid shows the hierarchy of the strongest types of medical evidence.
For more information on Evidence Based Practice, please visit the EBP section of the Medicine Subject Guide:
For more information on reference managers, see the Reference Management page of this guide.
Plan ahead. Systematic reviews normally take over a year to complete; be sure to allow ample time to produce the highest quality report possible.
Assemble a team. Systematic reviews are never produced independently, but rely on a team of experts working together.
Brush up on your search skills. Be sure to familiarise yourself with advanced searching techniques, especially in the most common health sciences databases.
Know what's required. For the purpose of transparency and reproducibility - the tenets of good science - your systematic review should adhere to guidelines on standards. For more information about these guidelines, click here.